In this research, responses of melon genotypes (Midyat, Şemame, Ananas, Yuva) that have determined salt tolerance levels were evaluated for leaf area, relative humidity, stomatal conductance, leaf water potential and leaf temperature under drought stress conditions. For this aim, in this study, three different watering levels (S0, S1 and S2) were used. (S0: control-plant-available water, 40% is consumed for irrigation, S1: plant-available water, 90% is consumed for irrigation, S2: during the period of 3-4 leaves of plants completely cut off from the irrigation). In the study, which is generally tolerant melon genotypes (Midyat and Şemame) close to the development of the control plants showed the face of drought stress, in turn, are sensitive to salt melon genotypes (Yuva and Ananas) were affected by the drought stress significantly. Midyat and Şemame genotypes leaf area under stress conditions, the relative humidity, the content, stomatal conductance, leaf temperature and leaf water potential values significantly, while retaining the same in terms of parameters of Yuva and Ananas genotypes markedly decreased compared with control plants. Tolerance to drought stress in determining the result of the study of leaf area, leaf temperature, stomatal conductance and concluded that one of the effective parameters.